Clinical Studies for Shingles, Herpes, and Hepatitis

(There are clinical studies topically related to our research here. We prefer to base our nutritional products on clinical studies more than testimonies. Some studies are listed at the end of particular articles. More can be found under the general topics of Monolaurin, Lactoferrin, Essential Oils, etc.)

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(We recommend adding lactoferrin to the Ultimate Monolaurin as mentioned in the Hepatitis and Lactoferrin articles. Lactoferrin has the same action against Shingles as Hepatitis:)

"Review article of studies which indicate that bovine lactoferrin is an effective anticancer agent in rat studies; capable of significantly inhibiting colon, esophagus, lung, bladder, and tongue carcinogenesis. It was also found that lactoferrin has significant anti-Hepatitis C virus activity; Hepatitis C is a leading cause of liver cancer in Japan."
Tsuda H, Sekine K, Fujita K, Ligo M. Cancer prevention by bovine lactoferrin and underlying mechanisms—A review of experimental and clinical studies. Biochemistry and Cell Biology, 80(1):131–136 (2002).

Against Enveloped RNA and DNA Viruses (which includes Shingles)

Hierholzer, J.C. and Kabara, J.J. In Vitro Effects of Monolaurin Compounds on Enveloped RNA and DNA Viruses. J. Of Food Safety 4:1-12 (1982)

Isaacs CE et al. (1994) Inactivation of enveloped viruses in human bodily fluids by purified lipids. Ann NY Acad Sci 724:457-464.

Isaacs CE and Schneidman K. (1991) Enveloped viruses in human and bovine milk are inactivated by added fatty acids(FAs) and monoglycerides(MGs). J FASEB 5: Abstract 5325, p.A1288.

Isaacs CE, Thormar H. Membrane-disruptive effect of human milk: inactivation of enveloped viruses. Journal of Infectious Diseases 1986; 154:966-971.

In vitro effects of monolaurin compounds on enveloped RNA and DNA viruses. Journal of Food Safety. 1982; 4: 1-12

Inactivation of Enveloped Viruses and killing of cells by Fatty Acids and Monoglycerides. Antimicrobial Agents and Chemotherapy. 1987 January; 31(1): 27-31

Sands, J, et al. Extreme sensitivity of enveloped viruses, including Herpes Simplex, to long chain unsaturated monoglycerides and alcohols, Antimicrobial Agents and Chemotherapy. 15; 1:67-73, 1979.

Thormar H et al. (1987) Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrobial Agents Chemother 31:27-31.

Thormar, H., C. E. Isaacs, K. S. Kim, and H. R. Brown. 1994. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann. N. Y. Acad. Sci. 724:465–471.

General Monolaurin Shingles, Hepatitis and Herpes Related Articles:

Beauman JG. Genital herpes: a review. Am Fam Physician. 2005 Oct 15;72(8):1527-34. Review.

Frobert E, Ooka T, Cortay JC, et al. Resistance of Herpes simplex virus type 1 to acyclovir: Thymidine kinase gene mutagenesis study. Antiviral Res 2006 Aug 30;epub ahead of print.

Fujihara T, Hayashi K (1995). "Lactoferrin inhibits herpes simplex virus type-1 (HSV-1) infection to mouse cornea". Arch. Virol. 140 (8): 1469–72.

Gaby AR. Natural remedies for Herpes simplex. Altern Med Rev. 2006 Jun;11(2):93-101. Review.

Griffith RS, Walsh DE, Myrmel KH, Thmpson RW, Behforooz A. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica. 1987;175(4):183-190.

Hierholzer, J.C. and Kabara, J.J. In Vitro Effects of Monolaurin Compounds on Enveloped RNA and DNA Viruses (Hepatitis). J. Of Food Safety 4:1-12 (1982)

In vitro effects of monolaurin compounds on enveloped RNA and DNA viruses (Hepatitis). Journal of Food Safety. 1982; 4: 1-12

Sands, J, et al. Extreme sensitivity of enveloped viruses, including Herpes Simplex, to long chain unsaturated monoglycerides and alcohols, Antimicrobial Agents and Chemotherapy. 15; 1:67-73, 1979.

Singh BB, Udani J, Vinjamury SP, et al., Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev. 2005;10(2):123-7.

(And more related studies):

Antimicrobial Lipids: Natural and Synthetic Fatty Acids and Monoglycerides. Kabara. J.J., Vrable, R. and Lie Ken Jie, M.S.F Lipids 12:753759 (1977).

Civitelli R, Villareal DT, Agnusdei D, Nardi P, Avioli LV, Gennari C. Dietary L-lysine and calcium metabolism in humans. Nutrition. 1992;8(6):400-405.

De los Santos AR, Marti MI, Espinosa D, Di Girolamo G, Vinacur JC, Casadei A. Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain. Acta Physiol Pharmacol Ther Latinoam. 1998;48(1):52-58.

Di Girolamo G, Zmijanovich R, de los Santos AR, Marti ML, Terragno A. Lysine clonixinate in the treatment of primary dysmenorrhea. Acta Physiol Pharmacol Ther Latinoam. 1996;46(4):223-232.

Epstein SE, Speir E, Zhou YF, Guetta E, Leon M, Finkel T. The role of infection in restenosis and atherosclerosis: focus on cytomegalovirus. Lancet 19%;348 Supplement 1:513-17.

Fini M, Torricelli P, Giavaresi G, Carpi A, Nicolini A, Giardino R. Effect of L-lysine and L-arginine osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001;55(4):213-220.

Flodin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am Coll Nutr. 1997;16:7-21.

Furst P. Dietary L-lysine supplementation: a promising nutritional tool in the prophylaxis and treatment of osteoporosis. Nutrition. 1993;9(1):71-72.

Hierholzer, J.C. and Kabara, J.J. In Vitro Effects of Monolaurin Compounds on Enveloped RNA and DNA Viruses. J. Of Food Safety 4:1-12 (1982).

Homung B, Arntmann E, Sauer G. Lauric acid inhibits the maturation of vesicular storriatitis virus. Journal of General Virology 1994;75:353-361.

Isaacs CE and Schneidman K. (1991) Enveloped viruses in human and bovine milk are inactivated by added fatty acids(FAs) and monoglycerides(MGs). J FASEB 5: Abstract 5325, p.A1288.

Kabara. J.J.. Conley. A J.- Swieczkowski. D M. Ismail, I.A . Lie Ken Jie and Gunstone, F D. Fatty Acids and Derivatives as Antimicrobial Agents Antimicrobial Agents and Chemotherapy 2(l):23-28 (1972)

Macallan D. C., Noble C., Baldwin C., Foskett M., McManus T., Griffin G. E. Prospective analysis of patterns of weight change in stage IV human immunodeficiency virus infection. Am. J. Clin. Nutr. 1993; 58:417-424

Ósk Thorgeirsdóttir, Thórunn; Kristmundsdóttir, Thórdís; Thormar, Halldór; Axelsdóttir, Íris; Peter Holbrook. Source: Acta Odontologica Scandinavica, Volume 64, Number 1, Number 1/February 2006 , pp. 21-26(6), Publisher: Informa Healthcare

Toxicological, Bactericidal and Fungicidal Properties of Fatty Acids and Some Derivatives Kabara, J.J. JAOCS 56:760-767

Lauric oils as antimicrobial agents: theory of effect, scientific rationale, and dietary applications as adjunct nutritional support.

University of Pittsburg Medical School: http://www.upmc.com/healthatoz/pages/healthlibrary.aspx?chunkiid=21791